A medline search on cryolipolysis turned up these 4. Looks like there may be something to it
1. Lasers Surg Med. 2009 Dec;41(10):703-8.
Cryolipolysis for subcutaneous fat layer reduction.
Avram MM, Harry RS.
Dermatology Laser & Cosmetic Center, Massachusetts General Hospital, Boston,
Massachusetts 02114, USA. firstname.lastname@example.org
BACKGROUND AND OBJECTIVE: Cryolipolysis is a unique non-invasive method for the
selective reduction of fat cells with controlled, localized cooling. It is
important, therefore, to understand the potential efficacy and safety of this new
procedure for fat layer reduction. MATERIALS AND METHODS: A review of the
literature associated with cryolipolysis was performed to evaluate the findings
from pre-clinical and clinical studies with respect to the mechanism of action,
efficacy, and safety. RESULTS: Cryolipolysis has demonstrated efficacy in both
human and animal studies. Histology findings also confirm the selective reduction
of fat in both humans and animals, with evidence of a gradual thinning of the fat
layer over a period of two to four months. Importantly, cryolipolysis has not
produced any significant adverse side effects in studies to date and any noted
effects have been minor and temporary. CONCLUSION: Although the mechanism of
action for cryolipolysis is not yet completely understood, the efficacy and
safety of this non-invasive procedure for fat layer reduction has been
demonstrated in the studies available to data. Further studies willl assist in
identifying the mechanism and elucidate the full potential of this technology to
perform safe, non-invasive fat reduction for areas of local fat accumulation.
Copyright 2009 Wiley-Liss, Inc.
PMID: 20014262 [PubMed - in process]
2. Lasers Surg Med. 2009 Dec;41(10):785-90.
Non-invasive cryolipolysis for subcutaneous fat reduction does not affect serum
lipid levels or liver function tests.
Klein KB, Zelickson B, Riopelle JG, Okamoto E, Bachelor EP, Harry RS, Preciado
Endpoint LLC, Bainbridge Island, Washington 98110, USA.
BACKGROUND AND OBJECTIVE: Cryolipolysis provides a method of non-invasive fat
reduction that significantly reduces subcutaneous fat without injury to adjacent
tissues. Preliminary animal and human data have suggested that cryolipolysis has
no effect on serum lipid profiles or liver tests. This study was intended to more
fully document any effect of this procedure on lipid and liver-related blood
tests. STUDY DESIGN/MATERIALS AND METHODS: Forty subjects with fat bulges on
their flanks ("love handles") were treated bilaterally with a non-invasive device
(Zeltiq Aesthetics, Pleasanton, CA) that precisely cools tissue to achieve a
reduction in the fat layer. Serum lipid levels and liver tests were measured
prior to treatment, and at 1 day and 1, 4, 8, and 12 weeks post-treatment.
RESULTS: No meaningful changes in mean values were observed for any blood lipid
level or liver test at any point over the 12-week follow-up period. CONCLUSION:
Cryolipolysis, when used for reduction of subcutaneous flank fat, is not
associated with changes in serum lipids or liver test results. Copyright 2009
PMID: 20014252 [PubMed - in process]
3. Dermatol Surg. 2009 Oct;35(10):1462-70. Epub 2009 Jul 13.
Cryolipolysis for noninvasive fat cell destruction: initial results from a pig
Zelickson B, Egbert BM, Preciado J, Allison J, Springer K, Rhoades RW, Manstein
Department of Dermatology, University of Minnesota Medical School, Minneapolis,
Minnesota, USA. email@example.com
BACKGROUND: Liposuction is one of the most frequently performed cosmetic
procedures in the United States, but its cost and downtime has led to the
development of noninvasive approaches for adipose tissue reduction. OBJECTIVE: To
determine whether noninvasive controlled and selective destruction of fat cells
(Cryolipolysis) can selectively damage subcutaneous fat without causing damage to
the overlying skin or rise in lipid levels. METHODS: Three Yucatan pigs underwent
Cryolipolysis at 22 sites: 20 at cooling intensity factor (CIF) index 24.5 (-43.8
mW/cm(2)), one at CIF 24.9 (-44.7 mW/cm(2)), and one at CIF 25.4 (-45.6
mW/cm(2)). Treated areas were evaluated using photography, ultrasound, and gross
and microscopic pathology. Lipids were at various times points. One additional
pig underwent Cryolipolysis at various days before euthanasia. RESULTS: The
treatments resulted in a significant reduction in the superficial fat layer
without damage to the overlying skin. An inflammatory response triggered by
cold-induced apoptosis of adipocytes preceded the reduction in the fat layer.
Evaluation of lipids over a 3-month period following treatment demonstrated that
cholesterol and triglyceride values remained normal. CONCLUSIONS: Cryolipolysis
is worthy of further study because it has been shown to significantly decrease
subcutaneous fat and change body contour without causing damage to the overlying
skin and surrounding structures or deleterious changes in blood lipids.
PMID: 19614940 [PubMed - indexed for MEDLINE]
4. Aesthetic Plast Surg. 2009 Jul;33(4):482-8. Epub 2009 Mar 19.
Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral
Coleman SR, Sachdeva K, Egbert BM, Preciado J, Allison J.
Department of Surgery, NYU School of Medicine, 44 Hudson Street, New York, NY
10013, USA. LipoStructure@yahoo.com
BACKGROUND: Cryolipolysis provides a method for noninvasive fat reduction that
significantly reduces subcutaneous fat in a pig model without apparent damage to
skin and surrounding structures. This study aimed to determine whether fat
reduction in humans caused by cold exposure is associated with alteration in
local sensory function or nerve fibers. METHODS: In this study, 10 subjects were
treated with a prototype cooling device. Fat reduction was assessed in 9 of the
10 subjects via ultrasound before treatment and at the follow-up visit. Sensory
function was assessed by neurologic evaluation (n = 9), and biopsies (n = 1) were
collected for nerve staining. RESULTS: Treatment resulted in a normalized fat
layer reduction of 20.4% at 2 months and 25.5% at 6 months after treatment.
Transient reduction in sensation occurred in six of nine subjects assessed by
neurologic evaluation. However, all sensation returned by a mean of 3.6 weeks
after treatment. Biopsies showed no long-term change in nerve fiber structure.
There were no lasting sensory alterations or observations of skin damage in any
of the subjects evaluated. CONCLUSION: Noninvasive cryolipolysis results in
substantial fat reduction within 2 months of treatment without damage to skin.
The procedure is associated with modest reversible short-term changes in the
function of peripheral sensory nerves.
PMID: 19296153 [PubMed - indexed for MEDLINE]