Possible minor weight reducing effects occur in interventions using nicotine, but they are highly unreliable and likely mediated by lesser food intake rather than inherent
Chewing gum containing nicotine can increase the metabolic rate in a dose-dependent manner (3.7-4.9% with 1-2mg nicotine) when measured for the 180 minutes following 20
minutes of chewing.
Caffeine and Nicotine appear to have benefits together towards fat loss (due to additively being thermogenic, and synergistically suppressing appetite)
A decrease in penile girth in the flaccid state is noted, which is thought to be secondary to reduced blood flow
An acute suppression of growth hormone has been noted with nicotine to a small degree
Both nicotine and its metabolite cotinine appear to appear to negatively influence testicular structure and circulating testosterone levels