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  #11  
Unread 06-25-2013, 11:59 AM
acecombact1 acecombact1 is offline
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Okay, i have started using this stuff at 8mg ED. I thought i can report my experience, and make mini-updates here.


My experience so far, i have been using GW1516 for 5 days now. One noticeable side effect is extreme hunger around 30-40 min after taking my dose. This is strange, since PPARδ are thought to modulate appetite in positive way. However i found that most the appetite suppressants reports come from from rat studies, while a study done or a rat, shows very different effect of this drug on body composition and insulin sensitivity. Reference: http://www.ncbi.nlm.nih.gov/pubmed/20538899

Unfortunately, most studies done on human in vivo were performed by GlaxoSmithKline, and the data were not released to the public. So im not sure how this stuff will impact my insulin response. I found on other forum, that cyclist reported the hunger problem after taking GW1516. Im sure that its, the sole reason for my hunger pains, because its always happen directly after taking my dose.

Another interesting observation is that i noticed fluctuation in water retention. I usually read my weight, and take BIA reading with same level of hydration everyday. My BF reading with the BIA show a great variation, more than the norm. I also noticed that gained 3 lb of water weight during these 5 days, while keeping the same caloric deficit! My BF measurement using the caliper/skin fold test remained the same; which confirms that i have gained few pound of water weight. I also noticed the following: more frequent urination, trouble sleeping , more sweating, heat rash after workout (Miliaria crystallina, not sure if its caused by the drug). All are very mild in severity i would say.

Now the positive effect: The cardio effect

I usually run a mile in 10 min with 168 heart rate. This morning i ran a mile in 9:05 with 159 heart rate. This is significant for me since my cardiovascular performance didn't change in the last 3 months or more. This might be a placebo effect, but its very exiting nevertheless. i will keep monitoring my progress for the next month.
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  #12  
Unread 06-27-2013, 04:17 PM
acecombact1 acecombact1 is offline
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Update:

Im around the same weight today. The sides from the GW1516 are the same. Yesterday i was thinking that my experience with this this stuff is similar to entering ketosis for the first time. Low, energy, fogginess, bad breath!! and added extra hunger. I can only speculate why (increase in fatty acid oxidation in favor of glucose!), not sure. I think i maybe taking a large dose and need to lower it. My workout are the same so far.
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  #13  
Unread 01-24-2015, 05:45 PM
Burntwookie Burntwookie is offline
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Did you continue this experiment?
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  #14  
Unread 01-24-2015, 06:14 PM
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lylemcd lylemcd is offline
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  #15  
Unread 05-04-2017, 11:33 AM
ulmont ulmont is offline
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There was a new article on this GW1516 out this week:

Quote:
Management of energy stores is critical during endurance exercise; a shift in substrate utilization from glucose toward fat is a hallmark of trained muscle. Here we show that this key metabolic adaptation is both dependent on muscle PPARδ and stimulated by PPARδ ligand. Furthermore, we find that muscle PPARδ expression positively correlates with endurance performance in BXD mouse reference populations. In addition to stimulating fatty acid metabolism in sedentary mice, PPARδ activation potently suppresses glucose catabolism and does so without affecting either muscle fiber type or mitochondrial content. By preserving systemic glucose levels, PPARδ acts to delay the onset of hypoglycemia and extends running time by ∼100 min in treated mice. Collectively, these results identify a bifurcated PPARδ program that underlies glucose sparing and highlight the potential of PPARδ-targeted exercise mimetics in the treatment of metabolic disease, dystrophies, and, unavoidably, the enhancement of athletic performance.
http://www.cell.com/cell-metabolism/...131(17)30211-5
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  #16  
Unread 05-05-2017, 12:25 AM
Determinism Determinism is offline
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I there any study on humans?
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  #17  
Unread 06-03-2017, 08:03 PM
CharlieM CharlieM is offline
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Default Phase IV clinical trials

Well, this blog post from 2014 mentions a human study in Australia (footnote 6), it was not funded by Glaxo. I'm not sure if non-Glaxo funding is important or not:
https://runswimthrowcheat.blogspot.c...whats-all.html

This blog post informs that there was a Phase I clinical trial that was terminated early, no reason was given. Two Phase II trials ran to completion, sometime after which Glaxo announced it was ending research and development concerning this drug. It is apparently from these three studies that the risk of cancer and tumors are sourced. A Phase IV human trial was independently conducted in Australia, it reported no adverse effects.
https://theconversation.com/anti-dop...ndurobol-12997

Here, a number of individuals mention beginning use of it, discussion started about 3 years ago. One person mentions past use, current use, some of the benefits seen. The recommend cycles of use. Except for the one, none of them posted follow ups after their report of beginning use. None of them reported the extreme hunger that was reported here.
http://www.musclechemistry.com/uploa...endurobol.html

This is a decent-looking overview, with some interesting comments. One longer comment mentions only using it short-term, for recovery or as a prophylactic to prevent loss when it has been too long between exercise sessions. No long-term use, with the cancer risk cited as the reason why.
https://selfhacked.com/2016/09/09/gw...ksSide_Effects

About cancer risks:
  • They say the nitrates in bacon are carcinogenic, but bacon is still sold everywhere and is widely popular.
  • They say burned meat is carcinogenic, humans have been eating burned meat since the invention of fire. Cookouts are still widely popular.
  • Tobacco is carcinogenic but widely available, in use by a measurable segment of society.
  • Too much sun causes skin cancer. So do sunscreens that contain zinc oxide. Beaches are still crowded during the summer and there's no shortage of zinc oxide there.
  • Aluminum production is known to cause cancer. We won't be stopping the production of tinfoil or other goods made from aluminum any time soon. Ditto workplace exposures for iron and steel founding, rubber manufacturing.
  • Alcohol (ethanol) has been shown to cause some cancers and has been linked to others. It has been listed as a known human carcinogen since 1997.
So what is the real risk from endurobol aka cardarine aka GW501516 aka GW1516? That's what I want to know.
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  #18  
Unread 06-08-2017, 11:14 AM
MrSkinnyFat MrSkinnyFat is offline
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Never really cared much for the Ppar meds in the past,
Back in the day there was a lot of *ra ra* on the fibrates lopid ( or gemfibrozol...forgot exact spelling) and bezafibrate,

I did a brief stint on each one especially beza as it is both an alpha agonist alongside with i think some beta/delta

This was back when all of the rat studies made the rats get jacked as it brought some interest to lifters,

At best the beza perhaps prevented some fat gain from a small vacation binge but didnt notice anything in regards to extra fat loss,

Plus the sides were not worth it as it made you feel sore from even walking one flight stairs, i thnk studies show a decrease on test and muscle atrophy being possible,

Id rather sprint a few sessions of 100 to 200m wind sprints to get more of the change of shifting carb to fat for fuel for 23 hours of the day.
You get some AMPK activation which these ppar meds will not give you and a nice increase in insulin sensitivity with the sprints

Last edited by MrSkinnyFat : 06-08-2017 at 11:20 AM.
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  #19  
Unread 06-09-2017, 05:35 PM
CharlieM CharlieM is offline
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So... you don't have any direct experience with GW501516 then?
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  #20  
Unread 06-20-2017, 07:31 PM
MrSkinnyFat MrSkinnyFat is offline
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Quote:
Originally Posted by CharlieM View Post
So... you don't have any direct experience with GW501516 then?
Have you?
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