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  #1  
Unread 01-29-2018, 03:49 PM
Finch7 Finch7 is offline
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Join Date: Dec 2012
Posts: 3
Default Study: Ibuprofen alters human testicular physiology

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

http://www.pnas.org/content/115/4/E715.full

Abstract

Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named “compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.



Sounds like an interesting study, worth sharing since a lot of people here are worried about their testosterone levels
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  #2  
Unread 01-30-2018, 04:01 AM
lostmyoldaccount lostmyoldaccount is offline
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Join Date: Jun 2011
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> The study recruited 31 healthy white men, age 18–35 y.

lmao
__________________
Half-way measures don't get very far. You can only do one thing well at a time. Trying to gain muscle while losing fat will result in failure.

Get to 10% bodyfat first while lifting weights heavy 3x a week with reduced volume. Two weeks maintenance. Bulk up slowly (1 lb weight gain per week max), focus on getting stronger, measure body composition changes often.
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  #3  
Unread 01-30-2018, 11:48 AM
squat squat is offline
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Join Date: Feb 2013
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Quote:
Originally Posted by lostmyoldaccount View Post
> The study recruited 31 healthy white men, age 18–35 y.

lmao
It's a racist study!

Can't get the full picture without including some transgenders.
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  #4  
Unread 01-30-2018, 12:01 PM
w1cked w1cked is offline
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Join Date: Sep 2011
Posts: 1,725
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Quote:
Originally Posted by squat View Post
It's a racist study!

Can't get the full picture without including some transgenders.
Omg gender is a soshul construct u cisheteronormative troglodytes
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