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  #1451  
Unread 07-09-2016, 10:49 AM
LightCrow LightCrow is offline
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Quote:
Originally Posted by Beti ona View Post
And free radicals? You dont think need to take more antioxidants?
You lost the same weight with carb and ketosis?
There's no need for extra antioxidants beyond what's in your normal multi, like I said. Conciliator was only recommending standard doses 500-1000 mg/day vitamin C and 400-800 IU/day vitamin E.

With calories being equal I lost the same fat on carbs <100g a day versus letting them go higher to 200~g a day. I lost it easier and quicker on the higher carbs due to fewer binges and mentally was a lot better. I generally don't respond well to ketogenic diets though, so just my n=1 perspective.
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  #1452  
Unread 07-09-2016, 04:23 PM
Beti ona Beti ona is offline
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Quote:
Originally Posted by LightCrow View Post
There's no need for extra antioxidants beyond what's in your normal multi, like I said. Conciliator was only recommending standard doses 500-1000 mg/day vitamin C and 400-800 IU/day vitamin E.

My multivitamin have 80 mg of vitamin C and 67 IU of vitamin E.

I take those doses.

With calories being equal I lost the same fat on carbs <100g a day versus letting them go higher to 200~g a day. I lost it easier and quicker on the higher carbs due to fewer binges and mentally was a lot better. I generally don't respond well to ketogenic diets though, so just my n=1 perspective.
Thank you.

If you dont use high doses and not eliminate much fat diet, I believe that cravings can be controlled. I love ketogenic diets.
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  #1453  
Unread 08-03-2016, 11:03 AM
Beti ona Beti ona is offline
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MESO-Rx: You have done a lot of work with DNP. What is DNP? How does it work?

Dan Duchaine: Forty percent of your energy expenditure in your body…40% of the calories that you consume everyday is burned up as non-essential heat. Sixty percent of the energy is needed for metabolic processes, and to keep the cells alive and the processes involved. Forty percent is futile heat energy: there is no work being done, there is no ATP being used or produced for work. In humans, that is controlled by uncoupling proteins in light fat and skeletal muscle. UCPs, 2’s and 3’s, mediated by mostly beta-4 receptors in skeletal muscles and light fat. Dinitrophenol is an industrial chemical that has direct action on the heat production action in the mitochondria without any kind of receptor… it bypasses any kind of receptor or uncoupling protein. It pretty much throws protons off fatty acids and it turns into heat rather than ATP. It was a very popular weight loss drug in the 40s in this country but in that very unregulated time there were a lot of mis-prescribing and misuse of it and a high incidence of cataracts in women. And so it was banned from interstate transport although a doctor in almost every state could still prescribe it as long as they made the DNP within the state.

MESO-Rx: What causes the cataracts? What other problems occur?

Dan: Depletion of antioxidants in the eyeball specifically glutathione and Vitamin C. I always suspected it was the Vitamin C because the early research pointed out there was a depletion of Vitamin C in the cells, especially in the eyeball. Just recently, a couple of weeks ago, most newspapers reported a study that suggested supplemental Vitamin C could help avoid most cataracts.

Not everybody stays on it forever because you feel so miserable on it. I think most of the people having trouble with DNP don’t understand it. There was a misunderstanding of how DNP worked as opposed to other thermogenic agents in that we couldn’t really rely on measured body temperature to adjust the dosage. The human body can withstand a moderate fever, the body temperature can go well over a hundred degrees and you are kind of uncomfortable but you live, but it is not insufferable high. Because DNP allows the dilation of skin cells so that a lot of the heat is being radiated off, your body temperature is very, very high even though the mouth thermometer is really not showing a tremendous rise in body temperature. A 30 percent rise above normal, and your body temperature is only about 99.2 degrees. The hazard is that just because you have been able to tolerate ephedrine or yohimbe or clenbuterol in the past, temperatures of like a hundred or so, you should not try to get you body temperature that high on DNP because once it is that high you are well over double the metabolic rate and many of your cells are depleted of the energy source and things can get dangerous at that point.

MESO-Rx: You have recommended the use of insulin to enhance the efficacy of DNP use in bodybuilders…

Dan: It is not so much my idea but a research scientist out of the 30s that recommended it. Protein synthesis stops on DNP. Luckily for most sedentary people the research has not really shown a loss of muscle mass although it would stop testosterone production out of the gonads and might interfere with the transference of testosterone in the cells. However, they did show a study where by supplementing the DNP with growth hormone and insulin, they re-established protein synthesis. However, I must tell you about half of the heat producing ability of DNP comes from glucose being burned as heat and the other is fatty acids; so, if you put more glucose in your cells with insulin, you will become more uncomfortable because there will be more heat put off. We’ve done it both ways… we’ve done DNP with no insulin and those with it, and they were better off with it. We didn’t need much, maybe once a day with short-acting stuff.

MESO-Rx: You have recommended the use of insulin to enhance the efficacy of DNP use in bodybuilders…

Dan: It is not so much my idea but a research scientist out of the 30s that recommended it. Protein synthesis stops on DNP. Luckily for most sedentary people the research has not really shown a loss of muscle mass although it would stop testosterone production out of the gonads and might interfere with the transference of testosterone in the cells. However, they did show a study where by supplementing the DNP with growth hormone and insulin, they re-established protein synthesis. However, I must tell you about half of the heat producing ability of DNP comes from glucose being burned as heat and the other is fatty acids; so, if you put more glucose in your cells with insulin, you will become more uncomfortable because there will be more heat put off. We’ve done it both ways… we’ve done DNP with no insulin and those with it, and they were better off with it. We didn’t need much, maybe once a day with short-acting stuff.

MESO-Rx: Do you think DNP, ipriflavone, and insulin are possible alternatives to steroids?

Dan: A few women have used DNP. I’m afraid to say that a lot of women did suffer on DNP because they were using too much more than necessary. I say that because they get in shape in such a fast time, they’re ready 3 or 4 weeks before the contest and they really suffer to get there because their body temperature is so elevated. Now looking back, we could have used ˝ maybe 1/3 the dosage and took our time so that we peaked right on time rather than way ahead of time.

Ipriflavone from Italy, the other from Hungary…As much as I begged people to get it in the country, it has never shown up. I’ve never seen one box of that stuff being used. I don’t know why. Usually, I have a pretty good track record of recommending something and suddenly it shows up here, but that never made it over here.
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  #1454  
Unread 08-03-2016, 01:32 PM
highwire highwire is offline
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Quote:
Protein synthesis stops on DNP
Does this mean it's pointless to weight train while on DNP? And is it dosage dependent? Like 200mg stops 50%, 400mg stops 100%?
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  #1455  
Unread 08-03-2016, 08:30 PM
rishi45 rishi45 is offline
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Hey guys,

In considering DNP usage, I've read through this thread in its entirety and countless anecdotal reports on other forums (although it's clear that this thread has some of the more reputable and well-researched commentary on this drug). I had finally decided to take the plunge and ordered some caps, which arrived today. However, staring at them right now I am having serious concerns and anxiety all stemming from the possibility of developing PN.

At first, I thought that PN generally only affected long time users and/or inferno cyclers but then I read a few horror stories including
this.

I have read a few shocking reports of low-dose, short duration runs that promptly ended with varying levels of PN development. I have noticed that in most if not all of these cases users exhibit tremendous weight loss on "low" dosages of DNP in a relatively short amount of time (in the linked case above the user saw 10lbs of loss after shedding water weight with only 9 days of use at 250mg ED). Thus, my hypothesis is that if one starts with a conservative low-dose DNP cycle and the results are markedly greater than what that person should expect for their height, bf%, etc., it is an indication of oversensitivity to DNP, which very likely leads to PN.

Please let me know if this sounds reasonable. I am hoping that as a community we can get closer to identifying PN-prone users before symptoms escalate.
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  #1456  
Unread 08-04-2016, 01:27 AM
dben3428 dben3428 is offline
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Started today with 250mg. running for 14 days with an isocaloric diet. 4 hours in and feeling the heat!
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  #1457  
Unread 08-04-2016, 06:21 AM
Beti ona Beti ona is offline
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Quote:
Originally Posted by highwire View Post
Does this mean it's pointless to weight train while on DNP? And is it dosage dependent? Like 200mg stops 50%, 400mg stops 100%?
http://dinitrophenol.net/weight-trai...muscle-on-dnp/
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  #1458  
Unread 08-08-2016, 04:31 PM
dickinanus dickinanus is offline
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I have 65 caps @ 125mg each. It's a little hot here and I'm not on a strict deadline, so is the best way to use this just to take 250 a day for 4 weeks?

I've been doing cardio 2x a day and alternate day fasting and dropped a ton of weight. I pin gh 2 hours before every cardio session and weight train every other day. Can I still do all this with DNP? I was going to lower my clen dose to 40mcg and switch to a diet of 50c/200p/30f.
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  #1459  
Unread 08-09-2016, 06:13 AM
Beti ona Beti ona is offline
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Join Date: Jun 2015
Posts: 85
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Quote:
Originally Posted by rishi45 View Post
Hey guys,

In considering DNP usage, I've read through this thread in its entirety and countless anecdotal reports on other forums (although it's clear that this thread has some of the more reputable and well-researched commentary on this drug). I had finally decided to take the plunge and ordered some caps, which arrived today. However, staring at them right now I am having serious concerns and anxiety all stemming from the possibility of developing PN.

At first, I thought that PN generally only affected long time users and/or inferno cyclers but then I read a few horror stories including
this.

I have read a few shocking reports of low-dose, short duration runs that promptly ended with varying levels of PN development. I have noticed that in most if not all of these cases users exhibit tremendous weight loss on "low" dosages of DNP in a relatively short amount of time (in the linked case above the user saw 10lbs of loss after shedding water weight with only 9 days of use at 250mg ED). Thus, my hypothesis is that if one starts with a conservative low-dose DNP cycle and the results are markedly greater than what that person should expect for their height, bf%, etc., it is an indication of oversensitivity to DNP, which very likely leads to PN.

Please let me know if this sounds reasonable. I am hoping that as a community we can get closer to identifying PN-prone users before symptoms escalate.
Honestly, I run 225-325 mg daily in cycles of 8 days. I lose 1 or 2 pounds in each cycle, no more. May have relation between great fat loss with the possibility of developing NP?

Anyway, NP it was just 4 days. Just, another crazed and compulsive user.

Last edited by Beti ona : 08-09-2016 at 06:34 AM.
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  #1460  
Unread 10-08-2016, 01:13 AM
kinhell kinhell is offline
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I need to find a new source for the ready made caps in the UK. Any decent sources?
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