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  #21  
Unread 09-02-2009, 08:49 AM
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James Register James Register is offline
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Quote:
Originally Posted by lylemcd View Post
They are important.

next article.
I meant just sleep and sleep's importance.. too basic? Not all recovery techniques, that would be a big article
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  #22  
Unread 09-02-2009, 08:53 AM
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I have nothing to add to the topic that hasn't been covered endlessly elsewhere.
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  #23  
Unread 09-02-2009, 11:07 AM
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How about an article for maximizing goals while on hormone therapy? More specifically, biweekly testosterone shots that produce supraphisiologic levels during the first week, and normal to below normal levels the next.

Seems like many middle age and older men are on 200mg injections biweekly. Can these supraphisiologic levels be taken advantage of? At first glance it would seem doing lean mass gain (overfeeding and tension) during the supraphisiologic week, with dieting (underfeeding and cardio) during the normal/below normal week would be the most advantageous. Your articles: General Philosophies of Muscle Mass Gain, and Calorie Partitioning I & II set the stage for this.

But what if fat loss is your primary goal? Would it be best to underfeed during the supraphisiologic phase because it would keep you more anabolic than normal, then utilize the tension/overfeeding to keep you anabolic when levels are normal, or below?
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  #24  
Unread 09-02-2009, 11:15 AM
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I'm not a steroid guru, ask someone who might actually know what they are talking about.
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  #25  
Unread 09-03-2009, 09:26 AM
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I would like to see you either support/de-bunk the optimization of growth hormone in trained individuals. For example:

1. if you eat a meal right before bed, does it significantly impact GH levels, and/or does the fat content significantly contribute?
2. eating before working out - how soon? I have read some credible evidence that you should eat a full meal 2-3 hrs prior to workout to ensure proper hormonal environment and blood flow to muscles, not stomach. But in UD2 you propose some whey and carbs 30 min prior to workout. If you go the 30min prior route, should you avoid fats because it blunts GH release?
3. There have been studies done with Alpha-GPC declaring GH significantly increased, but those individuals were training first thing in morning and fasted. What gives, the A-GPC or the fasted state?
4. Just how lypolytic is GH - supposedly the most of all hormones
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  #26  
Unread 09-03-2009, 09:28 AM
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What's to debunk: injectable GH doesn't do anything for growth. Small pulses are irrelevant

**
1: J Appl Physiol. 1993 Jun;74(6):3073-6.

Short-term growth hormone treatment does not increase muscle protein synthesis in
experienced weight lifters.

Yarasheski KE, Zachweija JJ, Angelopoulos TJ, Bier DM.

Metabolism Division, Washington University School of Medicine, St. Louis,
Missouri 63110.

The purpose of this study was to determine whether recombinant human growth
hormone (GH) administration enhances muscle protein anabolism in experienced
weight lifters. The fractional rate of skeletal muscle protein synthesis and the
whole body rate of protein breakdown were determined during a constant
intravenous infusion of [13C]leucine in 7 young (23 +/- 2 yr; 86.2 +/- 4.6 kg)
healthy experienced male weight lifters before and at the end of 14 days of
subcutaneous GH administration (40 microgram.kg-1 x day-1). GH administration
increased fasting serum insulin-like growth factor-I (from 224 +/- 20 to 589 +/-
80 ng/ml, P = 0.002) but did not increase the fractional rate of muscle protein
synthesis (from 0.034 +/- 0.004 to 0.034 +/- 0.002%/h) or reduce the rate of
whole body protein breakdown (from 103 +/- 4 to 108 +/- 5 mumol.kg-1 x h-1).
These findings suggest that short-term GH treatment does not increase the rate of
muscle protein synthesis or reduce the rate of whole body protein breakdown,
metabolic alterations that would promote muscle protein anabolism in experienced
weight lifters attempting to further increase muscle mass.

Publication Types:
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

PMID: 8366011 [PubMed - indexed for MEDLINE]

2: Am J Physiol. 1992 Mar;262(3 Pt 1):E261-7.

Effect of growth hormone and resistance exercise on muscle growth in young men.

Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, Bier DM.

Department of Medicine, Washington University School of Medicine, St. Louis,
Missouri 63110.

The purpose of this study was to determine whether growth hormone (GH)
administration enhances the muscle anabolism associated with heavy-resistance
exercise. Sixteen men (21-34 yr) were assigned randomly to a resistance training
plus GH group (n = 7) or to a resistance training plus placebo group (n = 9). For
12 wk, both groups trained all major muscle groups in an identical fashion while
receiving 40 micrograms recombinant human GH.kg-1.day-1 or placebo. Fat-free mass
(FFM) and total body water increased (P less than 0.05) in both groups but more
(P less than 0.01) in the GH recipients. Whole body protein synthesis rate
increased more (P less than 0.03), and whole body protein balance was greater (P
= 0.01) in the GH-treated group, but quadriceps muscle protein synthesis rate,
torso and limb circumferences, and muscle strength did not increase more in the
GH-treated group. In the young men studied, resistance exercise with or without
GH resulted in similar increments in muscle size, strength, and muscle protein
synthesis, indicating that 1) the larger increase in FFM with GH treatment was
probably due to an increase in lean tissue other than skeletal muscle and 2)
resistance training supplemented with GH did not further enhance muscle anabolism
and function.

Publication Types:
Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

PMID: 1550219 [PubMed - indexed for MEDLINE]
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  #27  
Unread 09-03-2009, 10:08 AM
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It's amazing how much the admin at Fitness Black Book promotes the importance of exercised induced HGH for fat loss. He's got some interesting ideas (i.e. nutty) on training...like never doing any kind of resistance training for legs, always working out while fasted and don't eat anything for a few hours after working out. All this to help maximize your HGH pulses.
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  #28  
Unread 09-03-2009, 10:33 AM
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Fat Loss and muscle growth are not the same thing. GH has a minor role in lipolysis as I've mentioned in several books. It's certainly not primary but injectable GH does do nice things for fat loss. Small pulses are part of hte picture but again, far from primary.

Most of the 'Do this to jack up GH' for fat loss approaches work through other mechanisms. High volume = lots of calories burned and glycogen depletion, short rests = a hormonal profile like intervals.

Basically, what I wrote about in stubborn fat
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  #29  
Unread 09-03-2009, 12:37 PM
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Quote:
Originally Posted by lylemcd View Post
What's to debunk: injectable GH doesn't do anything for growth. Small pulses are irrelevant
I was not talking about exogenous-administered HGH. But you are saying there are no factors to optimize your endogenous GH production, with regards to dietary intake and workout parameters?
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  #30  
Unread 09-03-2009, 12:46 PM
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Endogenous production = small pulses
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