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  #21  
Unread 09-08-2014, 08:53 AM
jvc11 jvc11 is offline
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People aren't aware about the side effect of ARA like proinflammatory and immunosupportive effect ?
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  #22  
Unread 09-08-2014, 09:07 AM
w_llewellyn w_llewellyn is offline
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Quote:
Originally Posted by jvc11 View Post
People aren't aware about the side effect of ARA like proinflammatory and immunosupportive effect ?
ARA is just dietary substrate. Supplementation does not cause inflammation, it only supports the process where it is active. In health, this is highly targeted. Muscle growth, of course, requires it.

This link shows you the heath effects on ARA supplementation:

https://www.molecularnutrition.co/mm...ffects_ARA.png

During the Baylor study (1 g/d ARA plus resistance exercise) there was a significant REDUCTION in inflammatory markers.

ARA is considered immunosupportive, not suppressive.
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Discovered anabolic role of Arachidonic Acid (ARA)
Author of bestselling ANABOLICS Reference Guide series.
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  #23  
Unread 09-08-2014, 09:18 AM
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lylemcd lylemcd is offline
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Get a hobby, William.
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  #24  
Unread 09-08-2014, 10:44 AM
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amir85 amir85 is offline
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Originally Posted by w_llewellyn View Post
ARA is not a minor fatty acid. It is the root trigger of protein synthesis after resistance training; the only fatty acid with such a direct role in hypertrophy. It literally rewrites our understanding of the role EFAs play in muscle growth. The fact that you, a respected researcher in our field, continue to identify it is as a minor FA is proof that I haven't been doing enough.

There is ample evidence to support what I am writing here; you just need to open your mind and take a look. If you need a hand, Im here.

Incidentally, I have ARA on Google alert. I post on occasion, when it is an interesting discussion, or it involves someone I have respect for. Best to you, Lyle.
Could you kindly enlighten us with ample evidence (human studies) that demonstrate the significant role of arachidonic acid in muscle hypertrophy?
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  #25  
Unread 09-08-2014, 11:03 AM
w_llewellyn w_llewellyn is offline
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Originally Posted by amir85 View Post
Could you kindly enlighten us with ample evidence (human studies) that demonstrate the significant role of arachidonic acid in muscle hypertrophy?
The human exercise intervention studies with ARA have already been mentioned.

Baylor (human) found an increase in peak power, with statistical trends in bench press, average power, and total work, in experienced resistance trained men taking 1 g/day ARA for 50 days, in spite of being underpowered. The follow up at the University of Tampa (with better controls, more power) found statistically significant increases in peak power, average power, strength, muscle thickness, and DEXA LBM (3.57 lbs) in experienced resistance trained men taking 1.5 g/day ARA for 2 months.

Combine this with the in-vitro data discussing mechanism, such as the papers from as Markworth and Cameron-Smith, which found FP receptor involvement, mTOR stimulation, and myonuclear accretion with increased ARA concentrations... or the in-vitro we funded at Benedictine years ago that also found increased nuclear density and protein content, or the earlier two papers (human studies) from Trappe et al. demonstrating NSAIDS to block protein synthesis increases after resistance training specifically by inhibiting arachidonic acid conversion. This is not an inclusive list. There are others.
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William Llewellyn

CEO of Molecular Nutrition
Discovered anabolic role of Arachidonic Acid (ARA)
Author of bestselling ANABOLICS Reference Guide series.
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  #26  
Unread 09-08-2014, 11:39 AM
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amir85 amir85 is offline
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Quote:
Originally Posted by w_llewellyn View Post
The human exercise intervention studies with ARA have already been mentioned.

Baylor (human) found an increase in peak power, with statistical trends in bench press, average power, and total work, in experienced resistance trained men taking 1 g/day ARA for 50 days, in spite of being underpowered. The follow up at the University of Tampa (with better controls, more power) found statistically significant increases in peak power, average power, strength, muscle thickness, and DEXA LBM (3.57 lbs) in experienced resistance trained men taking 1.5 g/day ARA for 2 months.

Combine this with the in-vitro data discussing mechanism, such as the papers from as Markworth and Cameron-Smith, which found FP receptor involvement, mTOR stimulation, and myonuclear accretion with increased ARA concentrations... or the in-vitro we funded at Benedictine years ago that also found increased nuclear density and protein content, or the earlier two papers (human studies) from Trappe et al. demonstrating NSAIDS to block protein synthesis increases after resistance training specifically by inhibiting arachidonic acid conversion. This is not an inclusive list. There are others.
Baylor University you are referring to: http://www.jissn.com/content/4/1/21
Quote:
AA supplementation during resistance-training may enhance anaerobic capacity and lessen the inflammatory response to training. However, AA supplementation did not promote statistically greater gains in strength, muscle mass, or influence markers of muscle hypertrophy.
University of Tampa study:
Did any other accredited journals published this study besides Molecular Nutrition Supplement store?

There are others:
Please direct me towards other conclusive human studies?
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  #27  
Unread 09-08-2014, 01:12 PM
w_llewellyn w_llewellyn is offline
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Quote:
Originally Posted by amir85 View Post
Baylor University you are referring to: http://www.jissn.com/content/4/1/21


University of Tampa study:
Did any other accredited journals published this study besides Molecular Nutrition Supplement store?

There are others:
Please direct me towards other conclusive human studies?
If you want to distill this discussion down to only the two interventional studies on resistance-trained adults, then yes, those are the two. Baylor and Tampa.

The Tampa study was published as an abstract by the National Strength and Conditioning Association (NSCA), at their national conference this July 11,2014. The final paper will be submitted for publication shortly.
__________________
---
William Llewellyn

CEO of Molecular Nutrition
Discovered anabolic role of Arachidonic Acid (ARA)
Author of bestselling ANABOLICS Reference Guide series.

Last edited by w_llewellyn : 09-08-2014 at 01:23 PM.
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  #28  
Unread 09-08-2014, 01:49 PM
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amir85 amir85 is offline
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Quote:
Originally Posted by w_llewellyn View Post
If you want to distill this discussion down to only the two interventional studies on resistance-trained adults, then yes, those are the two. Baylor and Tampa.

The Tampa study was published as an abstract by the National Strength and Conditioning Association (NSCA), at their national conference this July 11,2014. The final paper will be submitted for publication shortly.
Result of Baylor University study:
Quote:
AA supplementation during resistance-training may enhance anaerobic capacity and lessen the inflammatory response to training. However, AA supplementation did not promote statistically greater gains in strength, muscle mass, or influence markers of muscle hypertrophy.
And no I don't want to distill to two studies. I want you to direct me towards your claimed "ample human studies" that conclusively demonstrate that arachidonic acid will lead to statistically significant gains ("game changer") on training population.
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  #29  
Unread 09-08-2014, 01:55 PM
w_llewellyn w_llewellyn is offline
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Baylor Study (ARA 1g/day for 50 days). You'll notice they reported a significant increase in peak power, and reduction in resting inflammation, with all the other performance variables approaching significance. "Approaching significance" means there was a change in the supplemented group, and it was "very likely" (80% or greater confidence) due to the intervention (ARA supplementation). Statistical significance is 95% ("extremely likely"). The study was underpowered, however, which made seeing statistical strength difficult. This is why we did the Tampa follow up, with tighter controls. You'll also notice Dr. Mike Roberts, lead on Baylor, is also part of the Tampa follow up.

Significant increase anaerobic peak power (8.5%)
(ARA: 1.2 W•kg-1 vs. PLA: -0.2 W•kg-1)

Significant attenuation of inflammatory marker IL-6
(ARA: 0.8 pgml-1 vs. PLA: 52.5 pgml-1)

Statistically strong increase in bench press 1-RM (11%)
(ARA: 25 lbs. vs. PLA: 17.6 lbs.)

Statistically strong increase in wingate total work (6%)
(ARA: 1,292 J vs. PLA: 510 J, P = 0.09)

Statistically strong increase in wingate mean power (3.5%)
(ARA: 0.3 Wkg-1) vs. PLA :0.2 Wkg-1)

So to be clear, we have TWO human exercise interventions, and BOTH show a significant effect on performance in trained populations, with the second, more tightly controlled study, showing everything with significance (LBM, strength, size, power). This is more than you'll find for 99% of what is sold in sports nutrition.

And again, I'd also advise you to look at the numerous studies showing the importance of COX-2 metabolites of ARA in skeletal muscle hypertrophy. This all paints a strong picture of how important this particular fatty acid is.

If you want to wait for more to pay any interest in this yourself, of course you are welcome to.
__________________
---
William Llewellyn

CEO of Molecular Nutrition
Discovered anabolic role of Arachidonic Acid (ARA)
Author of bestselling ANABOLICS Reference Guide series.

Last edited by w_llewellyn : 09-08-2014 at 02:01 PM.
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  #30  
Unread 09-08-2014, 01:56 PM
w_llewellyn w_llewellyn is offline
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Tampa, for comparison:

University of Tampa (ARA 1.5 g/d for 8 weeks):

Statistically significant increase in lean body mass (3%)
(ARA: 3.57 lbs. vs. PLA: .2 lbs.)

Statistically significant increase in muscle thickness (9.5%)
(ARA: .47 cm vs. PLA: .25 cm)

Statistically significant increase in total strength (15%)
(ARA: 110 lbs. vs. PLA: 75 lbs.)

Statistically significant increase in anaerobic peak power (10.7%)
(ARA: 77.6 W vs. PLA: 27.8 W)
__________________
---
William Llewellyn

CEO of Molecular Nutrition
Discovered anabolic role of Arachidonic Acid (ARA)
Author of bestselling ANABOLICS Reference Guide series.

Last edited by w_llewellyn : 09-08-2014 at 02:38 PM.
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