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  #11  
Unread 05-29-2015, 08:45 PM
ColeTrain ColeTrain is offline
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Quote:
Originally Posted by FatHomer View Post
I understand what you are saying. I just thought you said something about keeping chronically high levels of dopamine may cause damage to the DA-producing neurons thus might increase risk for Parkinsons.

Of course, that would mean that smokers are more likely to get Parkinson's than non smokers, and since you say smokers are less likely to get Parkinson's than that idea isn't valid.
Hmm.... nicotine gum, here I come!
Since you're not opposed to mouse models, here's nicotine and beta-amyloid peptides, i.e. suggests nicotine helps mitigate Alzheimer's. http://www.ncbi.nlm.nih.gov/pubmed/25683952

And a review on nicotine as a potential treatment for Parkinson's. http://www.ncbi.nlm.nih.gov/pubmed/25620929
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  #12  
Unread 05-29-2015, 11:06 PM
shady shady is offline
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I have a special interest in this topic. Here's a list of things I try to do/eat on a regular basis. Certainly there isn't level 1 evidence for this stuff, but all can be supported by at least some human data.
1. Exercise - most important and likely has the strongest support in the literature
2. Epa/Dha and olive oil
3. Berries particularly blueberries
4. Green tea
5. Occasional low dose nicotine
6. Occasional dark chocolate
7. Turmeric
8. Occasional alcohol
9. I take an ARB for high BP. May improve b-amyloid metabolism via upregulation of ACE. More importantly controls BP which is a risk for cognitive decline
10. Use your brain

Last edited by shady : 05-29-2015 at 11:08 PM.
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  #13  
Unread 05-30-2015, 01:32 PM
freiamaya's Avatar
freiamaya freiamaya is offline
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My mother has Alzheimer's.
I exercise.

I take Longvida Tumeric (not regular tumeric)

http://alzheimer.neurology.ucla.edu/Curcumin.html

I take cocoa extracts

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575938/

May add nicotine to the above as in nicotine separate and distinct from tobacco nicotine. Like Lyle says, nothing hard about that.

http://www.alzdiscovery.org/cognitiv...ition/nicotine

As far as I understand, all supplements may or may not work as there is no long term definitive scientific results with respect to outcomes and recommended doses. I'm just going with these and with crossed fingers.

If any company finds a scientifically proven preventive regime, they'll hit the motherlode. It's a top area of research right now given population statistics/demographics.
__________________
Highest-247lbs@5ft6
Goal-132lbs
Maint-130-135lbs

Date
Feb7-174lbs
Feb13-168
Mar6-171
Mar13-167
Mar20-167
Mar27-
Apr3-
Apr10-
Apr17-
Apr24-
May1-
Net -

RFL 11 Mar 2015 -196lbs

RD 1 (Mar11- May18) 196-166 (-9-3-2+1-5-3-3-2-2-2=-30)=-30

Break(May19-Jun15) 166-169 (+3+0+0+0=+3)=-27

RD 2 (Jun16-Jul13) 169-160 (-5-3-1-0=-9)=-36

Break(Jul13-Feb 6) 160-174 (total=+14)=-22

RD 3(Feb7-May1) 174-167(0-6+3-4-0=-7)=-29
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  #14  
Unread 06-01-2015, 12:14 AM
Jackedtastic Jackedtastic is offline
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Quote:
Originally Posted by shady View Post
I have a special interest in this topic. Here's a list of things I try to do/eat on a regular basis. Certainly there isn't level 1 evidence for this stuff, but all can be supported by at least some human data.
1. Exercise - most important and likely has the strongest support in the literature
2. Epa/Dha and olive oil
3. Berries particularly blueberries
4. Green tea
5. Occasional low dose nicotine
6. Occasional dark chocolate
7. Turmeric
8. Occasional alcohol
9. I take an ARB for high BP. May improve b-amyloid metabolism via upregulation of ACE. More importantly controls BP which is a risk for cognitive decline
10. Use your brain
Why do you say "occasional"? I mean, I think I can understand why that might be a good idea for the nicotine and alcohol, but why the dark chocolate? Or am I missunderstanding you and you're simply talking about what you personally do?
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  #15  
Unread 06-02-2015, 12:57 PM
FatHomer FatHomer is offline
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Quote:
Originally Posted by ColeTrain View Post
Since you're not opposed to mouse models, here's nicotine and beta-amyloid peptides, i.e. suggests nicotine helps mitigate Alzheimer's. http://www.ncbi.nlm.nih.gov/pubmed/25683952

And a review on nicotine as a potential treatment for Parkinson's. http://www.ncbi.nlm.nih.gov/pubmed/25620929
that 2nd link doesnt work.?

I tried some 5mg nicotine gum at work
WHOA, It made me hyper and gave me a headache, and I felt dizzy, maybe my BP increased? I chewed it for a while and then saved the rest for later.
is nicotine gum working the way

is nicotine gum work the same way that bromocriptine does?
http://www.ncbi.nlm.nih.gov/pubmed/11092065

or maybe I should try some wellbutrin?(which I'm sure my insurance would cover)

I'm sure which drug is best to prevent Alzheimer's...any ideas?
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  #16  
Unread 06-02-2015, 12:59 PM
lylemcd's Avatar
lylemcd lylemcd is offline
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1 mg gum is fine.
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  #17  
Unread 06-02-2015, 05:25 PM
shady shady is offline
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Quote:
Originally Posted by Jackedtastic View Post
Why do you say "occasional"? I mean, I think I can understand why that might be a good idea for the nicotine and alcohol, but why the dark chocolate? Or am I missunderstanding you and you're simply talking about what you personally do?
Occasional meaning it's what I do. I use nicotine when I need energy, but can't take it on a daily basis due to my job. Alcohol in moderation and chocolate only because I don't want to knock back a dark chocolate bar everyday.
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  #18  
Unread 06-02-2015, 08:54 PM
Superlifter Superlifter is offline
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How long can you safely use nicotine gum for? I was reading that long term it can cause the same sensitivity to insulin as smoking can. Any studies looking into this?
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  #19  
Unread 06-03-2015, 06:51 AM
nstojic nstojic is offline
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Fascinating discovery with groundbreaking implications.
http://www.sciencedaily.com/releases...0601122445.htm
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  #20  
Unread 06-03-2015, 07:32 AM
lylemcd's Avatar
lylemcd lylemcd is offline
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Sapolsky was writing about psychoneuroimmunology a decade ago
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